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Question asked by: bridgetdevries - 2 years ago

De arteriolen van deze kanalen eindigen in een capillaire glomerulus, en de initile plaatsen van ossificatie vinden plaats als meerdere brandpunten grenzend aan de glomeruli. Wanneer de ossificatie begint, hypertroferen en degenereren de chondrocyten naast de glomerulus van het kraakbeenkanaal, en verkalkt de omringende matrix. Dit proces wordt gevolgd door het verschijnen van circulair georinteerde lagen van hypertrofische en delende chondrocyten. Deze cellulaire opstelling lijkt dus op die van de groeizones in de physis. Omdat het bindweefsel in de kraakbeenkanalen doorloopt in het perichondrium, hebben deze cellen hetzelfde osteogene potentieel voor botvorming. Uiteindelijk versmelten deze foci tot n enkel secundair centrum van ossificatie, waardoor sponsachtig bot in de epifyse wordt gevormd.
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